Medical gloves in the era of coronavirus disease 2019 pandemic
The current coronavirus 2019 disease (COVID-19) pandemic has greatly changed our perspective of the risk for infection from contact, and the use of personal protective devices (PPDs) usually reserved for health care workers (HCWs) has spread to the general population, sometimes indiscriminately. As a result, medical glove stock has been depleted, but most of all medical gloves have become a source of medical concern., , , 
The World Health Organization (WHO) has warned about the limited protective efficacy of gloves. There is high risk for infection spread with their incorrect use that could instead favor the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Regular use of gloves for daily activities may lead to a false sense of protection and to an increased risk for self-contamination. This would involve the involuntary touching of the face or the spreading of fomites to desks, phones, and computers keyboards. A study has found that viruses can survive on gloves for 2 to 4 hours.5
Hand-to-face contact has a substantial role in upper respiratory tract infections,6 , 7 although COVID-19’s main way of transmission remains symptomatic person-to-person through respiratory droplets., , ,  The Centers for Disease Control and Prevention (CDC) and the European Center for Disease Prevention and Control (ECDC) have recently provided guidance to regulate the use of gloves both in the health care setting and in the community.2 , 4 In the context of the COVID-19 pandemic (Table 1 ), gloves are recommended when caring for confirmed or suspected COVID-19 patients, especially when there is the risk of contact with body fluids (eg, blood, wound care, aerosol-generating procedures).
Hand protection with gloves is essential in any medical procedure, because skin cleaning/disinfection alone does not remove all pathogens, especially when the contamination is considerably high. Nonsterile disposable gloves should be prioritized, and ECDC alerts that no direct evidence documents an increased protection against COVID-19 through glove use, compared with proper hand hygiene alone. Meticulous hand hygiene with water and soap or by alcohol-based hand rub solutions is not avoided by the use of gloves.
There are many different types of gloves, depending on the level of protection, tactility, risk of allergy, or cost (Table 2 ). Although biohazard risk requires frequent glove changing, the extended use of gloves, decontamination with hand disinfectants, and reuse are frequent.8 All of this should be avoided, because effects of hand sanitizers are tested on the skin, whereas application on gloved hands affects gloves’ mechanical properties. In a recent investigation,9 the application of 70% ethanol or 63% isopropanol commercial disinfectants reduced the tensile strength of latex and nitrile gloves, with a higher impact on nitrile gloves. Elongation did not change much with latex gloves, but nitrile gloves were affected. There are additional concerns about permeability, as alcohol can permeate any type of glove after 10 minutes. Some types of disposable gloves are permeated at 2 minutes, and repeated exposure to disinfectants can increase the permeability of the gloves. Alcohol is inactivated in the presence of organic matter, which can easily remain on used gloves, thus potentially driving the viral transmission.